Presentation Year

2022

Depreciated Participant

David MoralesChemistryUndergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

Snyder-Robinson Syndrome (SRS) is a disorder that is characterized by severe osteoporosis. SRS is caused by a mutated gene coding for Spermine Synthase (SMS). SMS converts spermidine into spermine. Therefore SRS patients show increased spermidine/spermine ratios. Using bone marrow-derived Multipotent Stromal Cells, we found that supplementation with spermidine inhibits differentiation. During osteogenic differentiation the polyamine catabolic enzyme Spermidine/Spermine Acetyltransferase (SAT1) is upregulated. Also, inhibition of polyamine synthesis directly promotes osteogenesis. Therefore our results in vitro suggest that reduction of polyamines is necessary for osteogenic differentiation.

Permission to Publish Work

Yes

Presentation File Upload

ideafest_poster_dam_042522.pptx (2.11 MB)

Node ID

1080

Page Classification