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Portrait of David Baston

Contact

david.baston@humboldt.edu
  • HIIMR

Areas of Expertise

  • Analytical Chemistry
  • Signal Transduction
  • Environmental Chemistry

Research Categories

  • Environmental Science

David Baston

Research Associate, Core Research Facility

My initial focus for my Bachelor and Master of Science was on the Fate and Transport of anthropogenic compounds in environmental and their effects on biological systems. During this time I also held a Student Hydrologist position at the U.S.G.S. in Sacramento working as an analytical chemist for the Toxic Substances and NAWQA programs evaluating water, groundwater, sediment, soil, and atmospheric samples for Current Use and Legacy pesticides. My Doctorate work integrated my previous environmental toxicology experience with cellular/molecular biology and signal transduction. This work included development, validation, and use of multiple Bioassays designed to provide a high-throughput semi-quantitative analysis of POPs in the environment. I continue to work with extracting, analyzing, and evaluating natural and anthropogenic compounds to determine their beneficial/detrimental effects on cellular and molecular signaling mechanisms. My current interests are: oncogenic initiation/promotion, environmental effects on gene expression and regulation, and monoculture impacts on the environment.

 

Accomplishments

Consult with cannabis industry regarding analysis and quantitation of pesticides and compounds of interest.

Grants

  • Nanocellect WOLF Cytometer. John W. Steele and David S. Baston. MRI, NSF. Submitted Jan 21, 2020.
  • Interdisciplinary Student Competition for the Designing, Testing, and Prototyping of Gel Transilluminator Boxes between Biology and Engineering. Tesfayohanes Yacob (and David S. Baston). Research, Scholarship, and Creative Activities Program (RSCA) AY 2019-20; Awarded: Oct 18, 2019; $3,477.00.
  • Micro Photonics SkyScan 1273 High-Energy Micro-CT Scanner for Research and Training in the Humboldt College of Natural Resources & Sciences, John O. Reiss, Paul Bourdeau, David S. Baston, Melissa Hawkins, Brandon L. Browne, MRI, NSF. Awarded Aug 20, 2019; $491,223.00.
  • Expand Genomics and Data Collection for Photophthora spp. Identification, David S. Baston, Lucy Kerhoulas, Christopher Lee, Susan E. Marshall, Agricultural Research Initiative (ARI) California State University, 2018-21; $60,518.
  • Improved genetic technique for rapid detection & identification of invasive Phytophthora spp. Susan E. Marshall, David S. Baston, and Christopher Lee. USDA Special Technology Development Program Grant - #17-DG-11052021-232, Forest Health, June 2017-2020, $153,950.00.
  • Improving Genetic Literacy in a Diverse Group of Rural University Students Using Personalized Genetic Testing. David S. Baston and Karen Kiemnec-Tyburczy, 23andMe Education Grant, Awarded February 2017; $17,000.00; declined.
  • Cigarette Smoke-Induced Oxidative Stress Injures Lung Epithelium via Activating Neutral Sphingomyelinase 2 (nSMase2)/Ceramide Generation. David S. Baston and Tzipora Goldkorn. NCI - T32, Two Year Postdoctoral Research and Training Program, Feb. 2012-June 2013. $40,000/yr stipend; $5000/yr materials.
  • Identification of Novel Compounds in Environmental Extracts Known to Stimulate Superinduction of the CALUX Bioassay by LC/MS Analysis. David S. Baston and Michael S. Denison. NIEHS Superfund Basic Research and Training Program, Jul. 2007-Mar. 2008. $21,000/yr stipend.
  • Identification and Characterization of Novel Environmental Contaminants that Enhance the Biological Potency of Dioxins and Related Chemicals. David S. Baston and Michael S. Denison.  NIEHS Superfund Basic Research and Training Program, Jul. 2006-Mar. 2007. 21,000/yr stipend.
  • Humate, Ionic Strength, and Pesticide Interactions on Suspended Clays. D.S. Baston and R.J.Zasoski, U.C. Toxic Substances Research and Training Program. David Baston and Robert. J. Zasoski. UCD-TSRTP, Jul. 1996-1998. $21,000/yr.

Book Chapters

Indirubins as activators of the aryl hydrocarbon receptor signal transduction pathway. Michael S. Denison, Dalho Han, Scott Nagy, Bin Zhao, David S. Baston, Ai Hayashi, Marie Knockaert, Laurent Meijer, Book Title: Indirubin, the red shade of indigo, Chapter 16,157-167, 2006.

Publications

(Articles resulting from support of the Cal Poly Humboldt CNRS Core Research Facility)

  • Wild Blueberries Increases Fat Oxidation Rate During Submaximal Exercise. Jessie Armendariz, Boe matthew Burrus, Kari Diane Pilolla, David S. Baston, Taylor Bloedon, European Journal of Applied Physiology, In process Jan. 2020,.
  • GTP Cyclohydrolase I Activity from Rickettsia monacensis Strain Humboldt, a Rickettsial Endosymbiont of Ixodes pacificus. Jianmin Zhong, James L. Bodnar, Sergio Fitch, Jessica Sanchez, Molly Lesser, David Baston; Ticks and Tick-Borne Diseases In Press Nov 29, 2019.
  • Pathogenicity of three Botryosphaeriaceae canker fungi isolated from coast redwood (Sequoia semprevirens) in California. Chrisopher A. Lee, Megan McCormick, Suzanne Rooney-Latham, David S. Baston. In process, Sept. 2019.

(Replication of a Published Materials Science Synthesis: An Impromptu Upper-Division Undergraduate inorganic Chemistry Laboratory Experiment. Marcos A. Amezcua et al, Chem Educator 2016, 21, 215-222.).

  • Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells. Filosto S, Baston DS, Chung S, Becker CR, Goldkorn T., Mol Cancer Ther. 2013 May 17, 1029.
  • CALUX Measurements: Statistical Inferences for the Dose Response Curve. Elskens M, Baston DS, Stumpf C, Haedrich J, Keupers I, Croes K, Denison MS, Baeyens W, Goeyens L. Talanta 2011, Sep. 30;85(4):2039-46.
  • Third Generation Ah Receptor-Responsive Luciferase Reporter Plasmids: Amplification of Dioxin Responsive Elements Dramatically increases CALUX Bioassay Sensitivity and Responsiveness. He G, Tsutsumi T, Zhao B, Baston DS, Shao J, Heath-Pagliuso S, Denison MS, Toxicol. Sci.2011, Jul. 20 (Epub).
  • Considerations for Potency Equivalent Calculations in the Ah Receptor-Based CALUX Bioassay: Normalization of Superinduction Results for Improved Sample Potency Estimation. David S. Baston and Michael S. Denison, Talanta, 15;83(5):1415-21, 2011.
  • Pre-validation study for dioxin and dioxin-like compound analysis in WWTP sludge with the CALUX bioassay - Emphasis on obtaining extracts suitable for both chemo- and bioanalytical determination. Van Langenhove K, Keupers I, Croes K, Vandermarken T, Denison M. S., Baston D. S., Elskens M., Baeyens W.; Organohalogen Compounds Vol. 73, 2132-2135 (2011).
  • Enhancing the Response of CALUX and CAFLUX Cell Bioassays for Quantitative Detection of Dioxin-Like Compounds. Bin Zhao, David S. Baston, Elaine Khan, Claudio Sorrentino and Michael S. Denison, Science China Chemistry Vol. 53 Number 5 1010-1016, 2010.
  • Analytical Characteristics of the H1L6.1 and the H1L7.5 Mouse Hepatoma Cell Lines. Kersten Van Langenhove, Kim Croes, Michael S. Denison, David S. Baston, Mark Elskens, and Willy Baeyens, Organohalogen Compounds Vol. 72, 1092-1096 (2010).
  • Species-Specific Third Generation (G3) Luciferase Cell Bioassays Show Dramatically Increased Sensitivity and Magnitude of Response to TCDD and Other AH Receptor Agonists. Guochun He, Tomoaki Tsutsumi, Bin Zhao, David S. Baston, and Michael S. Denison, Organohalogen Compounds 71: 002399-002403, 2009.
  • Mouse Breast Cancer Model-Dependent Changes in Metabolic Syndrome-Associated Phenotypes Caused by Maternal Dioxin Exposure and Dietary Fat. La Merrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW. Am J Physiol Endocrinol Metab. Jan.;296(1), 2009.
  • Analysis of Dioxins in Contaminated Soils with the CALUX and CAFLUX Bioassays, an Immunoassay, and Gas Chromatography/High-Resolution Mass Spectrometry. Malin Nording, Michael S. Denison, David (S) Baston, Ylva Persson, Erik Spinnel, and Peter Haglund, Environmental Toxicology and Chemistry, Vol.26, No.6, pp. 1122-1129, 2007.
  • Interaction of Diuron and Related Substituted Phenylureas with the Ah Receptor Pathway.  Bin Zhao, David S. Baston, Bruce Hammock, and Michael S. Denison, J Biochem Molecular Toxicology, Vol. 20, Number 3, 103-113, 2006.
  • Recombinant Cell Bioassay Systems for the Detection and Relative Quanitation of Halogenated Dioxins and Related Chemicals. Michael S. Denison, Bin Zhao, David S. Baston, George Clark, Hiroshi Murata, Dalho Han, Review, Talanta. 63(5):1123-1133, Aug. 8, 2004.
  • Atmospheric Transport of Pesticides in the Sacramento, California, Metropolitan Area, 1996-1997.  Michael S. Majewski and David S. Baston; USGS, Water Resources Investigation Report 02-4100, Jul. 2002.
  • Determination of Pesticides Associated with Suspended Sediments in the San Joaquin River, California, U.S.A., Using Gas Chromatography-Ion Trap Mass Spectrometry.  Brian A. Bergamaschi, David S. Baston, Kathryn L. Crepeau, and Kathryn M. Kuivila. USGS, Sacramento, CA: Toxicological and Environmental Chemistry, Vol. 69, 305-319; 1999.

Presentations

  • Cal Poly Humboldt Core Research Facility: What’s it all about? David S. Baston, Science on Tap, Blondies, Arcata CA., October 3, 2018.
  • 3D Printing: Evolution of a Technology, David S. Baston, Cal Poly Humboldt, 3D Technology Workshop 12-4 pm, May 6, 2016
  • Evaluating Effects of Fish Oil Replacement with Algal Oil (Schizochytrium sp.) in the Diet of Orncorhynchus mykiss. James L. Schwartz, Jayme Yee, David S. Baston, Rafael Cuevas Uribe. Aquaculture 2016, Student Spotlight Award Session; February 23, 2016.
  • Analytical Chemistry to Signal Transduction: Completing a Picture of Effect. David S. Baston, California NorthState University, College of Pharmacy, May 1, 2013.
  • Snapshots of Recent History Crop Protection Product Occurrences in the California Central Valley Environment. David S. Baston, DuPont Crop Protection Products, Newark, DE, Feb. 3, 2011
  • CALUX Bioassay: NIEHS SBRP Bioassay Network. David S. Baston and Michael S. Denison, EPA Risk Assessors Meeting, Seattle, WA. Oct. 8, 2008.
  • The CALUX Bioassay as Semi-quantitative Screen for Dioxin and Related Carcinogens to Evaluate Potential Human Risk from Environmental Samples. David S. Baston and Michael S. Denison, Molecular Oncology Conference, Novosibirsk State University, Novosibirsk, Russia. Oct. 2008.
  • Superinduction of the CALUX Bioassay by Environmental Extracts: Considerations in Sample Analysis and Potency Determination. David S. Baston, Elaine M. Khan and Michael S. Denison, Dioxin 2008, Birmingham, England. Aug. 2008.
  • Improvements in the CALUX Bioassay for Dioxin-Like Chemicals. David S. Baston, Bin Zhao, Tomoaki Tsutsumi, and Michael S. Denison, Agricultural and Environmental Chemistry Graduate Group Colloquium, 2007.
  • Application of the CALUX Recombinant cell Bioassay for Detection of Dioxins and Dioxin-Like Compounds (DLCs) in Environmental Matrices. David S. Baston and Michael S. Denison, Agricultural and Environmental Chemistry Graduate Group Colloquium, 2005 and 2006.

Posters

  • The presence of Toxoplasma gondii in Brown Rats (Rattus vorvegicus) in Arcata, California. Nadia El Adli, Emily Armstrong Buck, David S. Baston, Richard Brown. Annual Wildlife Symposium, Dec 13, 2019, Cal Poly Humboldt, Arcata, CA.
  • Wild Blueberries Increase Fat Oxidation Rate During Moderate Intensity Exercise. Jessie Armendariz, Boe Burrus, Kari Pilolla, David (S.) Baston, Taylor Bloedon; ASCM 67th Annual Meeting, May 26-30, 2020, San Francisco, CA.
  • Direct Oomycete DNA Extraction from Soils Using Modified Shorty Buffer. Emma Gray, Maribel Perez Espinal, Darina Trendafilova, Chris Lee, David S. Baston and Susan B. Edinger-Marshall. SSSA International Annual Meetings (2019), SSSA Division: Soil Biology and Biochemistry, Nov 10-13, 2019, San Antonio, Texas.
  • Spectroscopic Detection of Resazuring and Resorufin to Indicate Dehydrogenase Activity in Soil.; Megan F. Mitchell; David S. Baston, PhD; Susan E. Marshall, PhD; SSSA International Annual Meetings (2019), SSSA Division: Soil Biology and Biochemistry, Nov 10-13, 2019, San Antonio, Texas.
  • Improving Diagnostics for the Lurking Pathogen, Phytophthora spp.. Maribel Perez Espinal, Christopher Lee, Susan E. Marshall, Stephanie Valencia, Darina Trendafilova, Emma Gray, Everett Hansen, Wendy Sutton, Paul Reeser, Dixie Blumenshine, David S. Baston. SACNAS, Oct 31-Nov 2, 2019, Honolulu Hawai’i.
  • Ramorum Leaf Blight Reduces Leaf-Level Productivity in Tanoak and California Bay. Weinberg W., Suoja J., Maberry R., Kerhoulas L., Lee C., Baston D.S., Marshall S.E.  ARI Conference, Oct 25, 2019; Sacramento, CA.
  • Impacts of Ocean Acidification on Intertidal Macroalgae and Algivore Preference. Andrea M. Fieber, David S. Baston, Paul E. Bourdeau: Western Society of Naturalists, Annual Meeting, Ensenada Mexico; November 3, 2019.
  • Phytophthora, Hide and Seek. Maribel Perez Espinal, Christopher Lee, Susan E. Marshall, Stephanie Valencia, Darina Trendafilova, Dixie Blumenshine, Andrea Goss, David S. Baston; INRSEP/CNRS Student Research Symposium, October 4, 2019.
  • Parallel Single Nucleotide Polymorphism (SNP) Assay Application for the Identification of Five Phytophthora spp.; Emma Gray, Maribel Perez Espinal, Darina Trendafilova, Lonyx  Landry, Chris Lee, Everett Hansen, Wendy Sutton, Paul Reeser, Susan B. Edinger-Marshall, and David S. Baston; The Seventh Sudden Oak Death Science and Management Symposium; Golden Gate Club, The Presidio, San Francisco, CA; June 25-27, 2019
  • Phytophthora, Hide and Seek. Maribel Perez Espinal, Christopher Lee, Susan E. Marshall, Stephanie Valencia, Darina Trendafilova, Dixie Blumenshine, Andrea Goss, David S. Baston; Annual Biomedical Research Conference for Minority Students (ABRCMS), Indianapolis Indiana, Nov 14-17, 2018.
  • Progress toward regulating the genome of Humulus lupulus L. (hops). Vannia Pena Robles Dewar, Susan Wright, Dr. Casey Lu, Dr. David S. Baston, Dr. John Steele; INRSEP/CNRS Scientific Research Symposium, Cal Poly Humboldt, Sept 28, 2018.
  • Nickel and Copper Concentrations in Jeffery Pine (Pinus jefferyi) seeds from Non-serpentine and Serpentine soils in Northern California. Selene Castillo, Dave Baston and Dan Barton, Senior Poster Session, Dept. of Wildlife, Cal Poly Humboldt, April 28, 2017.
  • Seasonal Variation in Isolation of Phytophthora from Wildland Soils. Scott Yamamoto, Christopher Lee, David S. Baston, Susan E. Marshall; Soil Science Society of America Annual Meeting, Phoenix AZ, November 6-9, 2016; Scott Yamamoto, Christopher Lee, David S. Baston, Susan E. Marshall; California Forest Pest Council, U. C. Davis, Davis, CA, November 15-16, 2017.
  • Determining the Presence of Borrelia burgdorferi s.l. in Barred Owls. Dacota K. Huzzen, David S. Baston, Richard N. Brown, Wildlife Senior Thesis, Cal Poly Humboldt, May 6, 2016.
  • Isolation and DNA Extraction of Phytophthora from Four Wildland Soil Types in Northern California, Humboldt County. Angelina Lasko, Christopher Lee, David S. Baston, Susan E. Marshall; Soil Science Society of America Annual Meeting, Minneapolis, MN, November 15-18, 2015
  • Src-mediated resistance to TKI in smoking-related lung cancer. David S. Baston, Simone Filosto, Samuel Chung and Tzipora Goldkorn, Lung Research Day Annual Meeting, U.C. Davis, Davis, CA. Apr. 29, 2013.
  • Neutral Sphingomyelinase 2 Activity and Expression In Lung Epithelium Exposed To Cigarette Smonke0Induced Oxidative Stress: Molecular Trigger For Lung Injury. Simone Filosto, Samuel Chung, David S. Baston, and Tzipora Goldkorn, American Thoracic Society International Conference; Pennsylvania Convention Center, May 19, 2013
  • Neutral Sphingomyelinase 2 (nSMase2) Activity and Protein Stability Under Cigarette Smoke Exposure in Lung Injury. David S. Baston, Samuel Chung, Simone Filosto, and Tzipora Goldkorn, Lung Research Day Annual Meeting, U.C. Davis, Davis, CA. Apr. 18, 2012.
  • Sample Potency Estimation Revisited: Reasons and Options for Employing a Linearized Potency Estimation Model (CALUX Data Linearization). Baston DS, Elskens M, Denison MS, Goeyens L, Baeyens W, Dioxin 2009 Annual Meeting, Beijing, China. Aug. 23-28, 2009.
  • Potential Human Risk Estimated from CALUX Bioassay Screening of Soil and Sediment Extracts for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Carcinogens. David S. Baston and Michael S. Denison, Novosibirsk State University, Novosibirsk, Russia. Oct. 2008.
  • Improvements in the CALUX Bioassay for Dioxin-like Chemicals. David S. Baston, Bin Zhao, Tomoaki Tsutsumi and Michael Denison.  Superfund Basic Research Program Annual Meeting, San Diego, CA. Dec. 2006.
  • Application of the CALUX Recombinant Cell Bioassay for Detection and Relative Quantitation of Halogenated Dioxins and Related Chemicals in Environmental Matrices. David S. Baston, David J. Brown, Michael Chu, George C. Clark, Hiroshi Murata and Michael S. Denison; Superfund Basic Research Program, Annual Meeting Seattle, WA. Nov. 2004.
  • Identification of Novel Agonists and Antagonists of the Ah Receptor Signal Transduction Pathway. Baston, DS, Nagy, SR, Nantz, M, Kurth, M, Springsteel, M, Denison, MS Dioxin 2003, Boston, MA. August, 2003.
  • Pesticides in Sediments: Does Grain Size Matter? David S. Baston and B.A. Bergamaschi USGS - Sacramento, CA, State of the Estuary Conference, Palace of Fine Arts, San Francisco, CA. Mar. 17-19, 1999.
  • Humic, pH, and Pesticide Interactions. D.S. Baston and R.J. Zasosk.11th Annual Research Symposium, U.C. Toxic Substances Research and Teaching Program, Apr. 17-18, 1998.
  • Humate, Ionic Strength, and Pesticide Interactions on Suspended Clays. D.S. Baston and R.J. Zasoski.10th Annual Research Symposium, U.C. Toxic Substances Research and Teaching Program, Apr. 11-12, 1997.