Presentation Year

2017

Depreciated Participant

Linh PhamBiologyUndergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

Interactions between stem cells and their microenvironment, or niche, are not thoroughly understood. The Drosophila testis stem cell niche provides a simple model to observe niche-stem cell interactions. This niche contains non-dividing hub cells that signal to adjacent germline stem cells and somatic cyst stem cells (CySCs). If the testis is damaged (specifically, if CySCs are eliminated) hub cells sense their absence and respond by dividing and changing their identity (or transdifferentiating), becoming replacement CySCs. Because transdifferentiation occur in many niches and can promote tumor formation, we are using Drosophila testes niche as a model to gain more insights on this process.

Permission to Publish Work

Yes

Node ID

247

Page Classification