Presentation Year

2015

Depreciated Participant

Manal Mosa Hosawi Biological SciencesGraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

The OCT4 gene is a POU class V transcription factor essential for establishment of the inner cell mass, pluripotency and self -renewal of embryonic stem cells (ESs). OCT4 gene expression is controlled by various mechanisms including transcription factor regulation. The AP-1 transcription factor c-Jun is known to affect proliferation, apoptosis, and cell survival. Its transcriptional activity is increased by phosphorylation of L40/42 by Jun N-terminal kinase (JNK). In this study, we examine the role of c-Jun on the regulation of Oct4 expression.

Permission to Publish Work

Yes

Node ID

39

Page Classification