Presentation Year

2016

Depreciated Participant

Hannah Y. CollinsBiological Science Undergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

In the Sprowles lab we are interested in understanding the cellular mechanisms involved in development and disease. One of the main projects in our lab is understanding the stem cell origin of glioblastoma, an aggressive and highly malignant form of brain cancer. We are investigating the role of Lethal Giant Larvae homolog 1 (Lgl1), a cell polarity protein and its role in tumor initiation and maintenance. Through the use of transgenic Lgl1 knockout mice we have isolated and propagated neural stem/progenitor cells from different region of the adult mouse brain and are investigating the functional consequences of Lgl1 deletion on signaling pathways often see to be dysregulated in cancer.

Permission to Publish Work

Yes

Node ID

179

Page Classification