Presentation Year

2016

Depreciated Participant

Lauren DahlBiological SciencesUndergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

This study examines a role for the JNK/c-Jun pathway in stem cell potency, differentiation, and Oct4 expression. Oct 4 is a transcription factor known to regulate genes involved in embryonic stem cell (ESC) self-renewal, pluripotency, and differentiation. cJun is a protein that regulates genes responsible for cell proliferation, differentiation and apoptosis. Its transcriptional activity is regulated in part by its activator, JUN amino-terminal kinase (JNK). In this study we modulated JNK/cJun signaling in murine embryonic stem cells through both chemical modulation of the JNK pathway and transient transfection of vectors expressing GFP cJUN, GFP L40/42A, GFP cJun R54A or GFP alone.

Permission to Publish Work

Yes

Node ID

180

Page Classification