Presentation Year

2016

Depreciated Participant

Jacqueline TrzeciakBiological SciencesUndergraduate Student,Abigail PetersenBiological SciencesUndergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

High grade gliomas are aggressive brain cancers that arise from tumor promoting neuronal progenitor cells. The WD40 protein Lethal Giant Larvae (LGL) may suppress brain tumor formation. Mice without LGL develop brain tumors and have a high level of apoptosis, or programmed cell death, which is a key feature of many cancers. cJun is an oncogene involved in cell division, organismal development and regulation of apoptosis through its role as a transcription factor. Apoptosis is mediated downstream by intracellular proteolytic enzymes called caspases. We aim to measure caspase activity in cells with and without LGL protein through observation of its effects on cJun expression.

Permission to Publish Work

Yes

Node ID

131

Page Classification