Presentation Year

2015

Depreciated Participant

Paige JeffordChemistryUndergraduate Student,Georgia KaufmanChemistryUndergraduate Student,Brian KyteChemistryFaculty

College or Department

Short Description of your Research or Creative Project (700 characters or less)

Certain Flavin Monooxygenases (FMO) are enzymes with the potential to catalyze single-enantiomer oxidation of aryl sulfides to chiral sulfoxides. Aryl sulfoxides have a wide array of pharmaceutical and agricultural applications, but many of these enantiomers have yet to be selectively and efficiently synthesized. The enzymes examined in this study are FMOs from Mus musculus, Xenopus tropicalis, Homo sapiens, and BVMO4 and BVMO24 from Rhodococcus jostii RHA1. The genes were cloned into a vector for expression in Escherichia coli and whole-cell mediated reactions with various aryl sulfides were performed to determine their activity toward the substrates and to determine the enantioselectivity.

Permission to Publish Work

Yes

Node ID

22

Page Classification