Presentation Year

2018

Depreciated Participant

Angelica RomeroBiological SciencesUndergraduate Student,Casiana GonzalesBiological SciencesUndergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

Gliomas are highly malignant intracranial tumors that result in a low survival rate due to an invasive phenotype and its diffuse nature. As a result, tumorigenic stem-like glioma cells are poorly targeted by conventional therapies. MAPK kinase 3 (MKK3) has been found to be a key upstream activator of the p38 MAPK protein and is upregulated in invasive glioma cells. Recent evidence suggests that interfering with MKK3 signaling through the inhibition of p38 can inhibit tumor cell invasion in vitro (Demuth et al. 2007). We are interested in examining the role of p38 in glioma through the ability of these cells to form tumor-like colonies in soft agar with modifications in Lgl1 gene expression

Permission to Publish Work

Yes

Node ID

455

Page Classification